Our new Obvious+ tissue clearing strategy is the only real process that delipidates samples with no alter in morphology and with nominal effect on structural integrity.

Megatome is usually a vibrating microtome designed to section a broad array of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With substantial blade vibrating frequency and minimized blade deflection, Megatome permits significant-throughput tissue sectioning with uniform area profile, as well as minimal tissue harm and data reduction.

Antibodies may take weeks to diffuse through only a few millimeters of tissue, with a steep labeling gradient from surface to Main.

Megatome is suitable for precision: the blade vibrates at the next frequency and bigger amplitude range than other microtomes, and includes a distinctive deflection Management system.

SE employs a rotational electric discipline to disperse extremely electromobile molecules (for instance antibodies or surfactant micelles) all over a porous sample without harming electrically billed constructions inside the tissue. This enables two-4 working day clearing of intact organs,

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Megatome is really a novel microtome that permits for prime-precision sectioning of a variety of tissue samples – from organoids, to arrays of animal organs, to intact human Mind hemispheres – with small tissue problems and data reduction.

eFLASH is often a immediate tissue labeling system that allows for uniform entire-organ staining in 20 rounds of labeling.

The SmartSPIM light sheet microscope provides unparalleled resolution and acquisition speed all over intact tissue volumes, although its modular structure lets you upgrade and personalize individual parts.

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Leverage the Clear+ tissue clearing technique, as well as eFLASH and patented stochastic electrotransport systems, to fast clear and label entire organs. Essential highlights and capabilities involve:

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